Sensitivity analysis of EGFR signaling pathway. The result shows that the migration potential of brain cancer cells is most sensitive to the initial concentration of EGFR (X2) and TGFα (X1). The result also shows us forward kinetic rates (k1, k2, k3, k5) are more important in the system and demonstrate that the developed intracellular pathway system is robust.
Sun et al. BMC Bioinformatics 2012 13:218 doi:10.1186/1471-2105-13-218