Simulation of vascular tumor growth without TKI treatment. (a) The evolution of vascular tumor patterns at 60, 90, 120 and 150 hours. (b) The distribution of glucose, oxygen, TGFα and VEGF in microenvironment at 150 hours. (c) Different types of cell numbers from 0 hour to 150 hours. (d) Proliferation rate of tumor cells derived from simulations (red line) and from in vitro experimental observations (blue line) for t=0-96 hours.
Sun et al. BMC Bioinformatics 2012 13:218 doi:10.1186/1471-2105-13-218