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Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: Incorporating EGFR signaling pathway and angiogenesis

Xiaoqiang Sun12, Le Zhang34*, Hua Tan5, Jiguang Bao2, Costas Strouthos6 and Xiaobo Zhou1*

Author Affiliations

1 Department of Radiology, The Methodist Hospital Research Institute, Weil Cornell Medical College, Houston, TX, 77030, USA

2 School of Mathematical Sciences, Beijing Normal University, Beijing, 100875, P R China

3 College of Computer and Information Science, Southwest University, Chongqing, 400715, P R China

4 Department of Mathematical Sciences, Michigan Technological University, Houghton, MI, 49931, USA

5 College of Global Change and Earth System Science, Beijing normal University, Beijing, 100875, P R China

6 Computation-based Science and Technology Research Center, The Cyprus Institute, Nicosia, 1645, Cyprus

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BMC Bioinformatics 2012, 13:218  doi:10.1186/1471-2105-13-218

Published: 30 August 2012

Additional files

Additional file 1:

Table A1. Kinetic equations describing the reactions between the components of the simplified EGFR signaling pathway.

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Additional file 2:

Table A2. Coefficients of the simplified EGFR signaling pathway.

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Additional file 3:

Table A3. Kinetic equations describing the reactions between the components of the cell-cycle.

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Table A4. Parameter in cell-cycle pathway.

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Additional file 5:

Table A5. Parameters of microenvironmental PDEs in the model.

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Additional file 6:

Text A1. Equations describing the Initial distribution of glucose, oxygen, TGFα, VEGF and fibronectin.

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Additional file 7:

Figure A1. Tumor induced angiogenesis and vascular tumor growth without TKI treatment.

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Figure A2. Vascular tumor growths with concentration change of fibronectin.

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Figure A3. The concentration change of glucose, oxygen, TGFα and VEGF without TKI treatment.

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Additional file 10:

Figure A4. Various tumor cell numbers without TKI treatment.

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Additional file 11:

Figure A5. Vascular tumor growth with TKI treatment.

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Additional file 12:

Figure A6. Vascular tumor growth in the presence of fibronectin with TKIs treatment.

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Additional file 13:

Figure A7. The concentration change of glucose, oxygen, TGFα and VEGF with TKI treatment.

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Additional file 14:

Figure A8. The concentration change of TKIs shown at 60, 150, 240 and 300 hours.

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Additional file 15:

Figure A9. Various tumor cell numbers with TKI treatment.

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