Results of the simulation study on the Insulin signaling pathway compound mediated signal propagation. Panel A. Signal paths selected to be differentially expressed. Panel B. p-value distribution of the topological analysis SPIA (pPERT) with and without propagation. Panel C. graphite network obtained from insulin pathway with propagation. Panel D. network obtained from insulin pathway without propagation.
Sales et al. BMC Bioinformatics 2012 13:20 doi:10.1186/1471-2105-13-20