Table 1

A comparison of web tools dedicated to molecular interactions.

MIR@NT@N

STRINGd

MotifMape

GeneMANIA

APIDf

InnateDB

InteractomeBrowser


Physical protein protein interactions

-

+

+

+

+

+

+

Computationally predicted TF targetsa

+

-

+

-

-

-

+

Experimentally observed TF targetsb

-

-

-

-

-

-

+

Database content

Predicted miRNA targets

+

-

-

-

-

-

+

Regulatory interactions from literature

-

+

-

-

-

-

+

Biological pathways

-

+

-

+

-

-

-

Inferred functional interactionsc

-

+

-

+

-

-

-


Batch query

+

+

-

+

-

-

+

Build-in graph visualizer

add/remove/hide inter-actors and interactions

-

-

-

-

+

-

+

Movable nodes

-

+

ND

+

+

+

+

Compartment-based layout

-

-

-

-

-

+

+


The table provides an overview of the types of molecular interactions and of the functionalities offered by representative web tools previously published. Informations were obtained from latest articles describing the servers. The presence or absence of the corresponding features is denoted by + or - respectively.

a Refers to bioinformatic prediction of TFBSs using PWMs.

b Refers to results from large-scale experimental methods that profile the binding of TFs to DNA at the genome-wide level (e.g.; ChIP-Seq, ChIP-chip, ...).

c Refers to computational methods that aggregate various informations (e.g.; expression, genomic distance, conservation) to infer functional interactions.

d Search Tool for the Retrieval of Interacting Genes/Proteins

e MotifMap visualizer was not available during our tests. Informations related to the visualizer were obtained from documentation.

f Agile Protein Interaction DataAnalyzer

Lepoivre et al. BMC Bioinformatics 2012 13:19   doi:10.1186/1471-2105-13-19

Open Data