Figure 3.

A network showing the reactions predicted from the eight source papers for the pantothenate and coenzyme A biosynthesis pathway. Squares are small molecules, circles are enzymes, and a pair of arrows is used to denote a single reaction (the first for the interaction substrate-enzyme, and the second for the interaction enzyme-product). Items labeled green are correct; items labeled red are incorrect. The number next to a reaction indicates the number of times that reaction was extracted from the set of source texts. The reactions on the right-hand side of the figure (lying outside the blue rectangle) are reactions extracted by our algorithm that are not part of the manually-annotated pantothenate and coenzyme A biosynthesis pathway from EcoCyc given in Figure 1.

Czarnecki et al. BMC Bioinformatics 2012 13:172   doi:10.1186/1471-2105-13-172
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