Figure 8.

Genome-wide association of phenotypes and CISs.A) Genome-wide map of CISs calculated using all tumors, colon tumors or liver tumors. The –log base 10 of the CISs p-value is plotted with an upper threshold of 16. B)Heat map of CISs with p-value > 10-5 calculated using all tumors. The header bar indicates colon tumors in dark grey and liver tumors in light grey. Transposon insertions in CIS regions within a given library are indicated by red boxes in the first panel. In the second panel the Fisher’s exact test p-value has been converted to the –log base 10 is plotted as a heatmap with increasing yellow intensity showing increased statistical significance. The CIS containing the Apc gene is highly significantly associated with colon tumors, while a CIS containing the Egfr gene is highly associated with the liver tumors. Actual p-values for association are provided in Additional file 1: Table S6.