Visual summary of the TAPDANCE process. Libraries of inserts from sets of mouse tumors are generated and sequenced. Barcode, IRDR and linker sequences are trimmed, and the remaining genomic sequence is mapped to the genome. Regions of insertions overrepresented within the genome and the statistical probablility of observing such events are determined in an automated manner allowing the comparison and contrasting of multiple datasets. Genomic loci may be common among many mice (e.g. F) or just a subset with a common observed phenotype or inherent genotype (e.g., G).
Sarver et al. BMC Bioinformatics 2012 13:154 doi:10.1186/1471-2105-13-154