Figure 2.

Comparison of Likelihood Assumptions in EMIM. Results from simulated data. (A-C) The power of likelihood ratio tests to achieve significance levels (p-values) of 0.001, 0.01 and 0.05 for different simulated effects and likelihood assumptions: HWE - Hardy-Weinberg Equilibrium; CEPG - Conditional on Exchangeable Parental Genotypes; CPG - Conditional on Parental Genotypes; PAE - Parental Allelic Exchangeability. (D-F) Box plots on a log-scale of parameter estimates for R1, R2, S1, S2and Im, assuming HWE. Dotted lines show the true parameter values.

Howey and Cordell BMC Bioinformatics 2012 13:149   doi:10.1186/1471-2105-13-149
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