Table 7

False positive rates when null hypothesis is simulated by generating random expression data
α=0.05 α=0.01
PADOG 0.051 0.012
GSA 0.052 0.015
GSEA 0.052 0.012

The fraction of all pathways significant at α=0.05 and α=0.01 were computed after applying the three analysis methods on 1200 datasets having expression data generated from a random normal N(0,1) distribution. The collection of gene sets used in the analysis was defined by the 229 KEGG non-metabolic and metabolic pathways.

Tarca et al.

Tarca et al. BMC Bioinformatics 2012 13:136   doi:10.1186/1471-2105-13-136

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