Table 4

Overlap and semantic similarity analyses between the ROCS and BioGRID lists of uniquely identified Specific Prey Proteins in all bait experiments
Bait Experiment ROCS Unique Prey Proteins (NB) ROCS Unique Specific Prey Proteins (SB) BioGRID Unique Specific Prey Proteins (B) BioGRID Intersection (X) BioGRID Intersection Significance (p-value) BioGRID Semantic Similarity (simRes(c1, c2))
BP MF CC
STK24 824 112 40 16 1.47041e-05 1.000 0.789 0.853
PPM1B 965 76 20 4 4.92866e-02 0.939 0.730 0.810
NME2 1349 260 26 18 2.58102e-08 0.939 1.000 0.937
CTNNBIP1 1229 69 13 6 3.00192e-05 0.939 1.000 1.000
VHL 5398 43 181 18 3.46865e-16 0.878 0.873 0.874

Hypergeometric test rejection probabilities (p-values) are given as well as protein lists semantic similarities for each gene ontology (Biological Process (BP), Molecular Function (MF), and Cellular Component (CC)). ROCS lists are reported for C − score CS > ĈScutoffand the marginal inclusion probability thresholds <a onClick="popup('http://www.biomedcentral.com/1471-2105/13/128/mathml/M246','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2105/13/128/mathml/M246">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1471-2105/13/128/mathml/M247','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2105/13/128/mathml/M247">View MathML</a> as determined in each AP-MS experiment.

Dazard et al.

Dazard et al. BMC Bioinformatics 2012 13:128   doi:10.1186/1471-2105-13-128

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