Table 2

Confident "driver" genes for breast cancer metastasis

Symbol

Entrez

Description


MAP2K1 [32]

5604

mitogen-activated protein kinase kinase 1

E2F1 [14]

1869

E2F transcription factor 1

GRB2 [33]

2885

growth factor receptor-bound protein 2

NFKB1 [34]

4790

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

RB1 [35]

5925

retinoblastoma 1

BRCA1 [36]

672

breast cancer 1, early onset

FOS [37]

2353

v-fos FBJ murine osteosarcoma viral oncogene homolog

SOS1 [38]

6654

son of sevenless homolog 1 (Drosophila)

PIK3CA [39]

5290

phosphoinositide-3-kinase, catalytic, alpha polypeptide

JAK1 [40]

3716

Janus kinase 1

SHC1 [41]

6464

SHC (Src homology 2 domain containing) transforming protein 1

MYC [42]

4609

v-myc myelocytomatosis viral oncogene homolog (avian)

CCNA2 [37]

890

cyclin A2


Yang et al. BMC Bioinformatics 2012 13:12   doi:10.1186/1471-2105-13-12

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