COMBINER biomarkers overlap with well-known cancer-related signalling pathways. The core module markers from CMI and CORG are listed in normal and italic fonts, respectively, while the common markers are in bold. Red/green color denotes up-/down-regulation. The remaining proteins in the circuit are abstracted as unlabeled nodes. The common core module markers of CMI- and CORG-COMBINER describe growth factors, survival factors, the cell cycle, and the extracellular matrix. Unique pathways to CMI-COMBINER include the anti-apoptosis and JAK-STAT cascade, while anti-growth factor and death factor pathways were discovered uniquely by CORG-COMBINER.
Yang et al. BMC Bioinformatics 2012 13:12 doi:10.1186/1471-2105-13-12