A framework for detecting protein complex and functional modules based on the combination of a PPI network and time-sequenced gene expressions. Clustering method 1 is used for predicting protein complexes while clustering method 2 is used for mining functional modules according to the identified complexes. In this framework, each previous clustering algorithm can be used as a candidate of clustering method 1 for identifying protein complexes as well as clustering method 2 for identifying functional modules.
Li et al. BMC Bioinformatics 2012 13:109 doi:10.1186/1471-2105-13-109