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This article is part of the supplement: UT-ORNL-KBRIN Bioinformatics Summit 2011

Open Access Meeting abstract

Identification of alcohol preference relevant genes in QTL on mouse chromosome 2

Lishi Wang1, Yan Jiao1, Griffin Gibson1, Xiaoyun Liu1, Yue Huang1, Beth Bennett2, Kristin Hamre3, Robert Williams3 and Weikuan Gu1*

Author Affiliations

1 Department of Orthopedic Surgery - Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

2 Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045-0508, USA

3 Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

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BMC Bioinformatics 2011, 12(Suppl 7):A2  doi:10.1186/1471-2105-12-S7-A2

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2105/12/S7/A2


Published:5 August 2011

© 2011 Wang et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Previously, a quantitative trait loci (QTL) for alcohol preference on chromosome 2 in a C57BL/6IBG (B6) background has been identified. The overlap of two of interval specific congenic recombinant strains (ISCRS) strains reduced the QTL interval into a 3.4 mbp region.

Results

By using the keyword alcohol, we identified a total of 39 genetic elements in the region between markers D2Mit56 and D2Mit10. Among these genetic elements, we found seven with potential function in alcohol preference (Table 1). We then examined the SNPs, insertions and deletions, and gene expression levels of those seven genes.

Table 1. Candidate genes for alcohol preference on Chr 2.

Conclusions

Our current data suggest that the Atf2 and Titin genes are potentially the most alcohol relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified.

Acknowledgments

Support for this research is partially from the NIAAA (1R01 AA016342). NIH, the Veterans Administration Medical Center, and DNA Discovery Core, University of Tennessee, Memphis, TN.