GOEAST analysis in molecular function category of T1D study. The GOEAST graphical output of enriched GO terms in the molecular function category for our selected gene network of T1D study. Boxes represent GO terms, labeled by its GO ID, term definition, and detailed information, organized as “q/m|t/k(p – value)”, where q is the count of genes associated with the listed GOID (directly or indirectly) in our dataset, m is the count of genes associated with the listed GOID (directly or indirectly) on the chosen platform, k is the total number of genes in our dataset, t is the total number of genes on the chosen platform, p-value is of the significance for the enrichment in the dataset of the listed GOID under hypergeometric distribution. Significantly enriched GO terms are marked yellow. The degree of color saturation of each node is positively correlated with the enrichment significance of the corresponding GO term. Nonsignificant GO terms within the hierarchical tree are shown as white boxes. Branches of the GO hierarchical tree without significantly enriched GO terms are not shown. Arrows represent connections between different GO terms. Red arrows represent relationships between two enriched GO terms, black solid arrows represent relationships between enriched and unenriched terms and black dashed arrows represent relationships between two unenriched GO terms.
Liu et al. BMC Bioinformatics 2011 12(Suppl 5):S4 doi:10.1186/1471-2105-12-S5-S4