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Open Access Highly Accessed Methodology article

Motif-guided sparse decomposition of gene expression data for regulatory module identification

Ting Gong1, Jianhua Xuan1*, Li Chen1, Rebecca B Riggins2, Huai Li3, Eric P Hoffman4, Robert Clarke2 and Yue Wang1

Author Affiliations

1 Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA

2 Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, USA

3 Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA

4 Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA

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BMC Bioinformatics 2011, 12:82  doi:10.1186/1471-2105-12-82

Published: 22 March 2011

Additional files

Additional file 1:

Supplementary material. Supplementary material includes supplementary method, tables and figures.

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Open Data

Additional file 2:

Target genes of four transcript ion factors (i.e., AP-1, ER, STAT and NFκB), respectively. The target gene lists can be found in 'Target_Genes_TFs.xls'.

Format: XLS Size: 34KB Download file

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Open Data