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Open Access Highly Accessed Software

CNV-WebStore: Online CNV Analysis, Storage and Interpretation

Geert Vandeweyer1, Edwin Reyniers12, Wim Wuyts2, Liesbeth Rooms1 and R Frank Kooy1*

Author Affiliations

1 Department of Medical Genetics, University Hospital Antwerp, Antwerp, Belgium

2 University Hospital Antwerp, Antwerp, Belgium

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BMC Bioinformatics 2011, 12:4  doi:10.1186/1471-2105-12-4

Published: 5 January 2011

Abstract

Background

Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system.

Results

We present CNV-WebStore, an online platform to streamline the processing and downstream interpretation of microarray data in a clinical context, tailored towards but not limited to the Illumina BeadArray platform. Provided analysis tools include CNV analsyis, parent of origin and uniparental disomy detection. Interpretation tools include data visualisation, gene prioritisation, automated PubMed searching, linking data to several genome browsers and annotation of CNVs based on several public databases. Finally a module is provided for uniform reporting of results.

Conclusion

CNV-WebStore is able to present copy number data in an intuitive way to both lab technicians and clinicians, making it a useful tool in daily clinical practice.