Effect of a mixture model likelihood on noisy gene classification. Using a mixture model likelihood allows BHC to model certain time points as outlier measurements for the genes shown, and assign the noisy gene to a cluster which is more coherent in its expression profiles and biological function. Outlier time points are time point 11 for FSP2, time point 2 for CMS3 and time point 4 for WcaC. The examples shown use BHC-SE for S. cerevisiae 1 and BHC-C for S. cerevisiae 2 and E.coli.
Cooke et al. BMC Bioinformatics 2011 12:399 doi:10.1186/1471-2105-12-399