Table 3 

Parameters of the lac operon models 

Symbol 
Value 
Units 
Description 


R_{0,E. coli} 
0.4 
μm 
E. coli radius 
L_{E. coli} 
2.3 
μm 
Representative E. coli length 
A_{E. coli} 
5.8 
μm^{2} 
E. coli membrane area (for the above length) 
V_{E. coli} 
1.0 
fL 
E. coli volume (for the above length) 
O_{T} 
1 
(copy number) 
operator molecular content 
k_{sMR} 
0.23 
nM·min^{1} 
lacI transcription rate 
k_{sR} 
15 
min^{1} 
LacI monomer translation rate constant 
k_{2R} 
50 
nM^{1}·min^{1} 
LacI dimerization rate constant 
k_{2R} 
10^{3} 
min^{1} 
LacI dimer dissociation rate constant 
k_{r} 
960 
nM^{1}·min^{1} 
association rate constant for repression 
k_{r} 
2.4 
min^{1} 
dissociation rate constant for repression 
k_{dr1} 
3·10^{7} 
nM^{2}·min^{1} 
association rate constant for 1^{st }derepression mechanism 
k_{dr1} 
12 
min^{1} 
dissociation rate constant for 1^{st }derepression mechanism 
k_{dr2} 
3·10^{7} 
nM^{2}·min^{1} 
association rate constant for 2^{nd }derepression mechanism 
k_{dr2} 
4.8·10^{3} 
nM^{1}·min^{1} 
dissociation rate constant for 2^{nd }derepression mechanism 
k_{s1MY} 
0.5 
min^{1} 
lacY transcription rate constant 
k_{s0MY} 
0.01 
min^{1} 
leak lacY transcription rate constant 
k_{sY} 
30 
min^{1} 
lacY translation rate constant 
k_{p} 
0.12 
nM^{1}·min^{1} 
LacYinducer association rate constant 
k_{p} 
0.1 
min^{1} 
LacYinducer dissociation rate constant 
k_{ft} 
6·10^{4} 
min^{1} 
TMG facilitated transport constant 
h_{t} 
1.55·10^{6} 
dm·min^{1} 
TMG passive diffusion permeability constant 
λ_{MR} 
0.462 
min^{1} 
lacI mRNA degradation constant 
λ_{MY} 
0.462 
min^{1} 
lacY mRNA degradation constant 
λ_{R} 
0.2 
min^{1} 
LacI monomer degradation constant 
λ_{R2} 
0.2 
min^{1} 
LacI dimer degradation constant 
λ_{Y} 
0.2 
min^{1} 
LacY degradation constant 
λ_{YIex} 
0.2 
min^{1} 
LacYinducer degradation constant 
λ_{I2R2} 
0.2 
min^{1} 
repressorinducer degradation constant 
g 
0.0231 
(min^{1}) 
cell growth rate parameter 
n_{d} 
25 
(dim/less) 
division propensity sharpness exponent 
V_{d,crit} 
15 
(fL) 
critical volume for division 
q 
80 
(dim/less) 
beta distribution sharpness exponent 
n_{s} 
25 
(dim/less) 
DNA duplication propensity sharpness exponent 
V_{s,crit} 
10 
(fL) 
critical volume for DNA duplication 


Stamatakis and Zygourakis BMC Bioinformatics 2011 12:301 doi:10.1186/1471210512301 