Comparison of the dynamical behavior of the CPME model that incorporates deterministic reaction dynamics with that of the structured continuum model. Parameters as in Table 3 unless otherwise noted. Panels (a, b): Transient dynamics of the population mean for the switching from the low ([Iex] = 0 μM) to the high state ([Iex] = 60 μM) (panel a) and conversely (panel b). For the dashed curve (continuum 1), the average values for [O]T and A/V were calculated from Eqs. 8 and 9, and for the dash-dotted curve (continuum 2) they were taken from the population simulations. Panel (c): As in panel (a) but with ks0MY = 0.025 min-1, ks1MY = 0.0005 min-1, λMY = 0.001155. Panel (d): The distribution of the division times (for comparison with the switching times).
Stamatakis and Zygourakis BMC Bioinformatics 2011 12:301 doi:10.1186/1471-2105-12-301