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Open Access Research article

Quantitative characterization and analysis of the dynamic NF-κB response in microglia

Patrick W Sheppard1, Xiaoyun Sun2, John F Emery2, Rona G Giffard2 and Mustafa Khammash1*

Author Affiliations

1 Department of Mechanical Engineering, University of California, Santa Barbara, Engineering II Bldg., Santa Barbara, CA, 93106-5070, USA

2 Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, 94305-5117, USA

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BMC Bioinformatics 2011, 12:276  doi:10.1186/1471-2105-12-276

Published: 5 July 2011

Additional files

Additional file 1:

Supplementary text and figures. The pdf contains supplementary text describing development of the mathematical model; Tables S1-S3 which list the model species, reactions, and rate parameters; and Figures S1-S8 that provide more detailed simulation results.

Format: PDF Size: 702KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

SBML model of microglial NF-κB activation. This .xml file is an SBML translation of the mathematical model originally developed in Matlab (MathWorks). Simulations correspond to the response of microglia cells following treatment with 10 ng/ml TNFα.

Format: XML Size: 30KB Download file

Open Data