Histograms illustrating the distribution of the derived allele frequencies for different SNP classes. Data for all three Perlegen populations (AFR, EUR, and CHN) are presented for the genome as a whole (green), ancestral repeats (red), and various SNP classes of functional significance (blue). Only resequenced Perlegen SNP markers are included in this analysis to minimize ascertainment bias. A) Evolutionarily constrained elements B) Constrained elements excluding genic regions C) Constrained elements excluding regions closer than 100 kb to an annotated gene D) H3K79me3 regions.
Levenstien and Klein BMC Bioinformatics 2011 12:26 doi:10.1186/1471-2105-12-26