Median fitness score of the individuals over generations. For each generation we calculate the median of the fitness scores of the 100 individuals per generation. At generation 1 the individuals are random while at generation 50 the individuals should be optimized according to the corresponding scoring function: (a) IEDB, (b) SYFPEITHI, (c) SVRMHC, (d) SVMHC and, (e) XSCORE. For all scoring functions except IEDB the optimum is a maximum (higher values indicate a higher binding affinity, e.g. pIC50-value). In IEDB the optimum is a minimum (lower values indicate a higher binding affinity, e.g. IC50-value). The selection operators are grouped by colour while the recombination operators are grouped by marker symbols. Only the data for the "single point amino acid mutation" is shown.
Knapp et al. BMC Bioinformatics 2011 12:241 doi:10.1186/1471-2105-12-241