Figure 5.

Receiver operating characteristic (ROC) curves of four tests of association. For the definition of the four statistics, see the caption of Figure 4. Assuming 500 cases and 500 controls, a set of 20,000 sites were simulated under the null and under the alternative at individual sequencing depths of 2×, 5×, and 10× (three columns). At each false positive rate (x-axis), the corresponding critical value was computed using the empirical null distribution. The true positive rate (power; y-axis) was obtained by computing the fraction of causative sites with test statistics that exceed the critical value.