Table 9

Top ranking co-occurring domains in novel human (CHD) interactions.

Domain Name A

Domain Name B

DOMINE

Number of sites

Zinc finger, LIM-type

Zinc finger, LIM-type

Known

28

Zinc finger, LIM-type

Zinc finger, C2H2-type

Known

25

Zinc finger, LIM-type

Actin-like

Known

25

Histone deacetylase

Zinc finger, C2H2-type

Known

23

Serine-threonine/tyrosine-protein kinase

Zinc finger, LIM-type

Known

23

Ankyrin repeat

EGF-like region, conserved site

Novel

22

EGF-like, type 3

EGF-like calcium-binding, conserved site

Novel

20

Zinc finger, LIM-type

Homeobox, region

Novel

16

Helix-loop-helix DNA-binding domain

Zinc finger, LIM-type

Known

15

Zinc finger, C2H2-type

Zinc finger, C2H2-type

Known

15

Out of the 100 most frequently occurring domain pairs, 55% are reported in the DOMINE database

Amos-Binks et al. BMC Bioinformatics 2011 12:225   doi:10.1186/1471-2105-12-225