Table 5

Top ranking co-occurring domains in high confidence binding sites from human

Domain Name A

Domain Name B

DOMINE


SH2 motif

Serine-threonine/tyrosine-protein kinase

Known

Serine-threonine/tyrosine-protein kinase

Insulin receptor substrate-1, PTB

Known

PDZ/DHR/GLGF

Cyclic AMP-dependent chloride channel

Novel

Serine-threonine/tyrosine-protein kinase

Phosphotyrosine interaction domain

Known

Serine-threonine/tyrosine-protein kinase

Serine-threonine/tyrosine-protein kinase

Known

PDZ/DHR/GLGF

Tyrosine-protein kinase, CSF-1/PDGF receptor

Novel

Src homology-3 domain

Serine/threonine-protein kinase-like domain

Known

SH2 motif

SH2 motif

Known

Src homology-3 domain

T-cell adhesion molecule CD2

Novel

7TM GPCR, rhodopsin-like

PDZ/DHR/GLGF

Known


Binding sites included in this analysis had DM ≤ 0.20. Among interacting domain pairs in all sites, 22 out of 47 (46.8%) pairs are reported in the DOMINE database.

Amos-Binks et al. BMC Bioinformatics 2011 12:225   doi:10.1186/1471-2105-12-225

Open Data