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This article is part of the supplement: Ninth International Conference on Bioinformatics (InCoB2010): Bioinformatics

Open Access Proceedings

Sensitivity analysis of dynamic biological systems with time-delays

Wu H Wu1, Feng S Wang2* and Maw S Chang1

1 Department of Computer Science and Information Engineering, National Chung Cheng University, Chiayi 62102, Taiwan

2 Department of Chemical Engineering, National Chung Cheng University, Chiayi 62102, Taiwan

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BMC Bioinformatics 2010, 11(Suppl 7):S12 doi:10.1186/1471-2105-11-S7-S12

Published: 15 October 2010

Additional files

Additional file 1:

TNF-α signal transduction model. This file includes the set of delay differential equations of the TNF-α signal transduction model, all of the relevant definitions of state variables, and the nominal values of parameters appearing in the delay differential equations.

Format: PDF Size: 49KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional file 2:

Manual of EAMCM program. This document provides a brief introduction to the extended adaptive modified collocation method (EAMCM) that we implemented to compute the solution and dynamic sensitivities of ordinal differential equation (ODE) and delay differential equation (DDE) systems.

Format: PDF Size: 226KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data