Research article
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants
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* Corresponding author: Jianwen Fang jwfang@ku.edu
1 Applied Bioinformatics Laboratory, the University of Kansas, Lawrence, KS 66047, USA
2 Department of Pharmaceutical Chemistry, the University of Kansas, Lawrence, KS 66047, USA
BMC Bioinformatics 2010, 11:62 doi:10.1186/1471-2105-11-62
Published: 28 January 2010Additional files
Additional file 1:
Supplementary Table S1, S2, and Figure S1. This file contains the following contents: 1. Table S1. Detailed description of the 10 features used to construct the scoring function. 2. Table S2. A test of the discriminative ability for the scoring function on a dataset containing 63 hyperthermophilic-mesophilic protein pairs and 310 thermophilic-mesophilic protein pairs. 3. Figure S1. The ROC curve of the scoring function in discrimination of 540 pairs of ortholog protein sequences accumulated from the 5-fold cross testing set.
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