Alignment algorithm. The system searches for the tallest peak (TP) in the 0-4.5 ppm range and for the three important peaks, in this order: Creatine, Choline and Lipid. If the SNR of the interesting peak is lower than five times the SNR of the TP, then the following peak is analysed in order to be chosen as reference. At the end, if one of the peaks is the chosen one for alignment, the spectrum is aligned and the process is terminated, otherwise the spectrum is left unchanged.
Pérez-Ruiz et al. BMC Bioinformatics 2010 11:581 doi:10.1186/1471-2105-11-581