Table 3 |
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|
Comparison of ARB, SMM-align and PROPRED's performance on current and old dataset. |
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|
Allelic variant |
ARB |
SMM-align |
PROPRED |
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|
|
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|
Current1 |
Old2 |
current1 |
old2 |
current1 |
old2 |
|
|
|
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|
HLA-DPA1*0103-DPB1*0201 |
0.823 |
0.921 |
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|
|
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|
HLA-DPA1*01-DPB1*0401 |
0.847 |
0.930 |
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|
|
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|
HLA-DPA1*0201-DPB1*0101 |
0.824 |
0.909 |
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|
|
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|
HLA-DPA1*0201-DPB1*0501 |
0.859 |
0.923 |
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|
|
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|
HLA-DPA1*0301-DPB1*0402 |
0.821 |
0.932 |
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|
|
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|
HLA-DQA1*0101-DQB1*0501 |
0.871 |
0.930 |
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|
|
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|
HLA-DQA1*0102-DQB1*0602 |
0.777 |
0.838 |
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|
|
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|
HLA-DQA1*0301-DQB1*0302 |
0.748 |
0.807 |
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|
|
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|
HLA-DQA1*0401-DQB1*0402 |
0.845 |
0.896 |
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|
|
||||||
|
HLA-DQA1*0501-DQB1*0201 |
0.855 |
0.901 |
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|
|
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|
HLA-DQA1*0501-DQB1*0301 |
0.844 |
0.910 |
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|
|
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|
HLA-DRB1*0101 |
0.770 |
0.764 |
0.798 |
0.769 |
0.720 |
0.738 |
|
|
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|
HLA-DRB1*0301 |
0.753 |
0.660 |
0.852 |
0.693 |
0.699 |
0.652 |
|
|
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|
HLA-DRB1*0401 |
0.731 |
0.667 |
0.781 |
0.684 |
0.737 |
0.686 |
|
|
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|
HLA-DRB1*0404 |
0.707 |
0.724 |
0.816 |
0.753 |
0.769 |
0.789 |
|
|
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|
HLA-DRB1*0405 |
0.771 |
0.669 |
0.822 |
0.694 |
0.767 |
0.750 |
|
|
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|
HLA-DRB1*0701 |
0.767 |
0.692 |
0.834 |
0.776 |
0.773 |
0.776 |
|
|
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|
HLA-DRB1*0802 |
0.702 |
0.737 |
0.741 |
0.750 |
0.647 |
0.768 |
|
|
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|
HLA-DRB1*0901 |
0.747 |
0.622 |
0.765 |
0.660 |
||
|
|
||||||
|
HLA-DRB1*1101 |
0.800 |
0.731 |
0.864 |
0.808 |
0.804 |
0.796 |
|
|
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|
HLA-DRB1*1302 |
0.727 |
0.787 |
0.797 |
0.695 |
0.600 |
0.584 |
|
|
||||||
|
HLA-DRB1*1501 |
0.763 |
0.700 |
0.796 |
0.738 |
0.743 |
0.715 |
|
|
||||||
|
HLA-DRB3*0101 |
0.709 |
0.590 |
0.819 |
0.677 |
||
|
|
||||||
|
HLA-DRB4*0101 |
0.785 |
0.741 |
0.816 |
0.713 |
||
|
|
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|
HLA-DRB5*0101 |
0.760 |
0.703 |
0.832 |
0.751 |
0.728 |
0.790 |
|
|
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|
H-2-IAb |
0.800 |
0.803 |
0.855 |
0.746 |
||
|
|
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|
Average |
0.784 |
0.706 |
0.849 |
0.727 |
0.726 |
0.731 |
|
|
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|
Min |
0.702 |
0.590 |
0.741 |
0.660 |
0.600 |
0.584 |
|
|
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|
Max |
0.871 |
0.803 |
0.932 |
0.808 |
0.804 |
0.796 |
|
|
||||||
|
Best prediction performance for each allelic variant was highlighted in bold. 1. The current AUC values for ARB and SMM-align were derived by cross-validation. The current AUC values for PROPRED were derived by predicting affinities for the new dataset. 2. The old AUC values were taken from previous evaluation [30]. |
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|
Wang et al. BMC Bioinformatics 2010 11:568 doi:10.1186/1471-2105-11-568 |
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