Table 3

Comparison of ARB, SMM-align and PROPRED's performance on current and old dataset.

Allelic variant

ARB

SMM-align

PROPRED


Current1

Old2

current1

old2

current1

old2


HLA-DPA1*0103-DPB1*0201

0.823

0.921


HLA-DPA1*01-DPB1*0401

0.847

0.930


HLA-DPA1*0201-DPB1*0101

0.824

0.909


HLA-DPA1*0201-DPB1*0501

0.859

0.923


HLA-DPA1*0301-DPB1*0402

0.821

0.932


HLA-DQA1*0101-DQB1*0501

0.871

0.930


HLA-DQA1*0102-DQB1*0602

0.777

0.838


HLA-DQA1*0301-DQB1*0302

0.748

0.807


HLA-DQA1*0401-DQB1*0402

0.845

0.896


HLA-DQA1*0501-DQB1*0201

0.855

0.901


HLA-DQA1*0501-DQB1*0301

0.844

0.910


HLA-DRB1*0101

0.770

0.764

0.798

0.769

0.720

0.738


HLA-DRB1*0301

0.753

0.660

0.852

0.693

0.699

0.652


HLA-DRB1*0401

0.731

0.667

0.781

0.684

0.737

0.686


HLA-DRB1*0404

0.707

0.724

0.816

0.753

0.769

0.789


HLA-DRB1*0405

0.771

0.669

0.822

0.694

0.767

0.750


HLA-DRB1*0701

0.767

0.692

0.834

0.776

0.773

0.776


HLA-DRB1*0802

0.702

0.737

0.741

0.750

0.647

0.768


HLA-DRB1*0901

0.747

0.622

0.765

0.660


HLA-DRB1*1101

0.800

0.731

0.864

0.808

0.804

0.796


HLA-DRB1*1302

0.727

0.787

0.797

0.695

0.600

0.584


HLA-DRB1*1501

0.763

0.700

0.796

0.738

0.743

0.715


HLA-DRB3*0101

0.709

0.590

0.819

0.677


HLA-DRB4*0101

0.785

0.741

0.816

0.713


HLA-DRB5*0101

0.760

0.703

0.832

0.751

0.728

0.790


H-2-IAb

0.800

0.803

0.855

0.746


Average

0.784

0.706

0.849

0.727

0.726

0.731


Min

0.702

0.590

0.741

0.660

0.600

0.584


Max

0.871

0.803

0.932

0.808

0.804

0.796


Best prediction performance for each allelic variant was highlighted in bold.

1. The current AUC values for ARB and SMM-align were derived by cross-validation. The current AUC values for PROPRED were derived by predicting affinities for the new dataset.

2. The old AUC values were taken from previous evaluation [30].

Wang et al. BMC Bioinformatics 2010 11:568   doi:10.1186/1471-2105-11-568

Open Data