Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
1 Department of Internal Medicine, The University of Iowa, 2294 CBRB, 285 Newton Road, Iowa City, IA 52242, USA
2 Department of Biomedical Engineering, The University of Iowa, 1402 Seamans Center, Iowa City, IA 52242, USA
BMC Bioinformatics 2010, 11:521 doi:10.1186/1471-2105-11-521Published: 19 October 2010
Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells. As the size of the interaction dataset increases, powerful computational methods are required in order to effectively distil network models from large-scale interactome data.
We present an algorithm, miPALM (
miPALM is a novel algorithm for detecting protein complexes from large protein-protein interaction networks with improved accuracy than previous methods. The software is implemented in Matlab and is freely available at http://www.medicine.uiowa.edu/Labs/tan/software.html webcite.