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QTLminer: identifying genes regulating quantitative traits

Rudi Alberts and Klaus Schughart*

Author Affiliations

Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstrasse 7, 38104 Braunschweig, Germany

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BMC Bioinformatics 2010, 11:516  doi:10.1186/1471-2105-11-516

Published: 15 October 2010

Abstract

Background

Quantitative trait locus (QTL) mapping identifies genomic regions that likely contain genes regulating a quantitative trait. However, QTL regions may encompass tens to hundreds of genes. To find the most promising candidate genes that regulate the trait, the biologist typically collects information from multiple resources about the genes in the QTL interval. This process is very laborious and time consuming.

Results

QTLminer is a bioinformatics tool that automatically performs QTL region analysis. It is available in GeneNetwork and it integrates information such as gene annotation, gene expression and sequence polymorphisms for all the genes within a given genomic interval.

Conclusions

QTLminer substantially speeds up discovery of the most promising candidate genes within a QTL region.