Table 19

Complexes derived with lesser accuracy or missed by MCL-CAw due to affinity scoring

Matched benchmark complex

#Proteins in complexes from

#Incorrect proteins in complexes from ICD(G+K)

Accuracies (Jaccard scores)

Name

#Proteins

G+K

ICD(G+K)

Missed

Addnl

G+K

ICD(G+K)


Kornbergs SRB

25

24

23

2

0

0.960

0.920

SWI/SNF

12

11

8

4

0

0.769

0.667

TRAPP

10

10

9

1

0

1.000

0.900

19/22 S reg

22

20

27

0

5

0.909

0.815


TRAMP

3

4

7

0

4

0.750

0.429

Alpha-1,6

5

9

11

0

6

0.556

0.455

eIF3

7

8

14

1

8

0.500

0.400

Protein phosp

3

5

9

0

4

0.600

0.333

Cdc73p/Paf1p

7

7

18

0

11

0.556

0.388

Chs5p/Arf-1

6

8

10

2

6

0.556

0.400


The upper half shows sample complexes from Wodak lab derived with lower accuracies from the ICD(Gavin+Krogan) network compared to those from the Gavin+Krogan network. The lower half shows those missed from the ICD(Gavin+Krogan) network. The #Incorrect proteins in ICD(Gavin+Krogan) network is with respect to the benchmark complexes.

Srihari et al. BMC Bioinformatics 2010 11:504   doi:10.1186/1471-2105-11-504

Open Data