Figure 3.

A sample microarray expression data set superimposed on a chromosome model. The figure integrates p53 knock-out expression data [23] and p53 binding site information within chromosome 19. It demonstrates how array data can be annotated on an existing physical model, and how large structural effects could be observed. The colored spheres show the magnitude of gene expression change when p53 is disrupted (green +/red -). Each sphere represents the transcription start site (TSS) of a gene. Cubes are placed at p53 binding sites, and are colored orange if close (< 10 kbp) to a measured gene expression TSS, yellow otherwise.