Tyrosine kinase homologoues with varying degrees of sequence conservation with different small molecules in their ATP-binding pocket. (a) Ephb2 Receptor Kinase domain with ADP. (b) Syk Tyrosine Kinase Domain in complex with Gleevec. (c) Ephb2 Receptor Tyrosine Kinase with Adenine.
Thangudu et al. BMC Bioinformatics 2010 11:365 doi:10.1186/1471-2105-11-365