Additional file 1:

Supplementary document. This document contains an introduction to Genetic Algorithms, a guideline for finding the lower bound of parameter α, and the probability plot comparing a mixture model of two normal distributions with a mixture of a normal and a t location scale distribution.

Format: PDF Size: 93KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 2:

Complete set of extracted subnetworks from sorafenib data. This file contains the set of all significant subnetworks and single nodes that have been extracted from the sorafenib mode of action data with SubExtractor. Two normal distributions as described in the Methods section were used to model the distribution of non-regulated and regulated phosphosites. The open source software Cytoscape http://www.cytoscape.org/ webcite is required to view this file. If the file has the format *.zip you have to re-name it to *.cys in order to be able to open it with Cytoscape.

Format: ZIP Size: 49KB Download file

Additional file 3:

List of extracted proteins from sorafenib data. This Excel file contains a list of all proteins that are part of a significantly regulated subnetwork extracted from the sorafenib mode of action data, along with their Uniprot accession numbers, combined z-scores and subnetwork affiliation.

Format: XLS Size: 77KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 4:

Complete set of extracted subnetworks from sorafenib data using a t distribution. This file essentially contains the same data as Additional file 2, but this time a t location scale distribution as described in the Normal Assumption subsection was used to model the distribution of differentially regulated phosphosites. The open source software Cytoscape http://www.cytoscape.org/ webcite is required to view this file. If the file has the format *.zip you have to re-name it to *.cys in order to be able to open it with Cytoscape.

Format: ZIP Size: 50KB Download file

Additional file 5:

Complete set of extracted subnetworks from sorafenib data using the alternative STRING data. This file contains the set of all significant subnetworks and single nodes that have been extracted from the sorafenib mode of action data with SubExtractor using the alternative STRING data described in the Alternative STRING network preparation subsection. The open source software Cytoscape http://www.cytoscape.org/ webcite is required to view this file. If the file has the format *.zip you have to re-name it to *.cys in order to be able to open it with Cytoscape.

Format: ZIP Size: 56KB Download file