Schematic representation of the optimization procedure. 1) the native structure is decomposed into contact maps based on different definitions, 2) the 3D structure is reconstructed from contact information only, obtaining an ensemble of conformations, 3) the accuracy is measured against the original structure. The protein shown is PDB structure 1bxyA. The ensemble corresponds to 6 reconstructions (ribbon representation) in different colours and also contains the native protein (cartoon representation) in blue.
Duarte et al. BMC Bioinformatics 2010 11:283 doi:10.1186/1471-2105-11-283