Figure 11.

Total number of observed (solid black curve) or predicted mutations in the 2,702 sequences of the PI2+ cohort for the 10-residue group 20-32-46-48-53-54-58-74-82-90 (A) and the 15-residue group 10-20-33-36-46-54-55-63-71-73-74-82-84-90-93 (B). The dashed curves represent the predictions for the independent (blue), pair-term (red), and pair+three-body model (green, not fit for the 15-residue group).