Additional file 9.
Genes in Drosophila. Example of visible genes in Drosophila melanogaster chromosome 2L. Exons are accompanied by a faint, though recognizable, 3-mer frequency pattern caused by the codon bias of the organism. Potential exons can be visually identified using Skittle without any other knowledge. In the Human genome, exons are sometimes also visually recognizable because of a sudden change in nucleotide bias towards GC rich content (Additional File 1).
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Seaman and Sanford BMC Bioinformatics 2009 10:452 doi:10.1186/1471-2105-10-452