Additional file 1.

Comparison of a real DNA sequence and a randomly generated sequence. A) This sequence is taken from Human Chromosome 10. It was chosen at random and contains no tandem repeats. Changing nucleotide bias can be seen, as reflected by regions which are AT-rich (black and blue) and regions which are GC-rich (green and red). B) The random sequence, in contrast, has no higher level patterns. This sequence was generated by a computer using a pseudo-random number generator.

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Seaman and Sanford BMC Bioinformatics 2009 10:452   doi:10.1186/1471-2105-10-452