Figure 2.

Mapping of bisulfite reads. 1) Increased search space due to the cytosine-thymine conversion in the bisulfite treatment. 2) Mapping asymmetry: thymines in bisulfite reads can be aligned with cytosines in the reference (illustrated in blue) but not the reverse.

Xi and Li BMC Bioinformatics 2009 10:232   doi:10.1186/1471-2105-10-232
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