Table 1

Mean percentage of significant cases detected when the null hypothesis was always true.

N

S

Sα

SB

BH

SGoF


t-test

5

100

4.95 ± 0.421

0.042 ± 0.0139

0.046 ± 0.0171

0.047 ± 0.0306

5

1000

5.02 ± 0.237

0.006 ± 0.0016

0.007 ± 0.0020

0.008 ± 0.0265

5

10000

5.00 ± 0.129

0.001 ± 0.0002

0.001 ± 0.0002

0.002 ± 0.0116

10

100

4.97 ± 0.412

0.063 ± 0.0184

0.068 ± 0.0209

0.042 ± 0.0485

10

1000

4.97 ± 0.236

0.005 ± 0.0015

0.005 ± 0.0016

0.007 ± 0.0275

10

10000

5.00 ± 0.130

0.000 ± 0.0001

0.000 ± 0.0002

0.002 ± 0.0079

20

100

5.03 ± 0.419

0.045 ± 0.0157

0.052 ± 0.0194

0.045 ± 0.0294

20

1000

4.99 ± 0.233

0.006 ± 0.0021

0.006 ± 0.0025

0.004 ± 0.0076

20

10000

5.02 ± 0.130

0.001 ± 0.0001

0.001 ± 0.0002

0.002 ± 0.0087


Mean

0.019 ± 0.0242

0.021 ± 0.0267

0.018 ± 0.0204


20

100

5.16 ± 0.421

0.049 ± 0.0149

0.052 ± 0.0166

0.046 ± 0.0356

20

1000

5.21 ± 0.239

0.004 ± 0.0014

0.004 ± 0.0017

0.014 ± 0.0157

G-test

20

10000

5.22 ± 0.133

0.001 ± 0.0001

0.001 ± 0.0003

0.019 ± 0.0558

40

100

5.05 ± 0.427

0.084 ± 0.0217

0.092 ± 0.0282

0.066 ± 0.0546

40

1000

5.12 ± 0.239

0.003 ± 0.0014

0.004 ± 0.0021

0.008 ± 0.0108

40

10000

5.09 ± 0.132

0.001 ± 0.0002

0.001 ± 0.0002

0.005 ± 0.0215

Mean

0.024 ± 0.0350

0.026 ± 0.0381

0.026 ± 0.0243


Values are averages through 1,000 replicates and their ± standard deviations. The simulated null models were tested under t or homogeneity G tests (see text). N: sample size. S: number of tests. Sα: Percentage of significant tests. SB: Sequential Bonferroni. BH: Benjamini and Hochberg. SGoF: Sequential Goodness of Fit.

Carvajal-Rodríguez et al. BMC Bioinformatics 2009 10:209   doi:10.1186/1471-2105-10-209

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