Table 1

GO Categories for the Rank-Invariant Genes

Gene

Cellular Component

Molecular Function

Biological Processes


GAPDH

Cytoplasm

Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity; protein binding

Glycolysis


ENO1

--

Phosphopyruvate hydratase activity

--


HSPCB

Cytoplasm

Nitric-oxide synthase regulator activity; nitric-oxide synthase regulator activity

Response to unfolded protein; positive regulation of nitric oxide biosynthetic process


ACTB

Cytoplasm; cytoskeleton

Protein binding; structural constituent of cytoskeleton

Cell motility


EEF1A1

Cytoplasm; eukaryotic elongation factor 1 complex

GTP binding; protein binding

Translational elongation


The GO categories are listed for the five genes in the rank-invariant set that were identified as reasonable controls to be used for normalization of the PMA dataset. The presence of GAPDH and ACTB as controls were not surprising for this dataset. The inclusion of some of the other categories heat-shock protein activity and translation, were more surprising.

Mar et al. BMC Bioinformatics 2009 10:110   doi:10.1186/1471-2105-10-110

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