Comparison of Hs-laforin with laforin orthologs from five vertebrate species. A. Amino acid sequence alignment of Hs-laforin and five laforin orthologs. Dark grey indicates identical residues, while similar residues are highlighted in light grey. Resides in red boxes are invariant residues as defined by the CBM20 family ; blue boxes indicate residues that are part of the phosphatase catalytic site. Locations of 42 missense mutations in Hs-laforin associated with LD are marked with arrows. The numbering of amino acids corresponds to the Hs-laforin sequence. B. Percent similarity and identity of Hs-laforin compared with laforin orthologs from other vertebrates.
Brewer et al. BMC Biochemistry 2014 15:8 doi:10.1186/1471-2091-15-8