Comparison of NPP family member crystal structures in the absence (magenta) and presence (blue) of ligand. A. Comparison of Xac. NPP crystal structures 2GSO and 2GSU (with AMP). All-atom RMSD for residues within 4.5 Å of AMP is 0.017 Å. B. Comparison of mouse NPP2 crystal structures 3NKM and 3NKP (with LPA). All-atom RMSD for residues within 4.5 Å of LPA is 0.44 Å. Glu308 is labeled to emphasize the sidechain showing the largest difference between the free and bound forms of the enzyme.
Parrill et al. BMC Biochemistry 2011 12:65 doi:10.1186/1471-2091-12-65