Figure 1.

The X-ray crystal structure of BoNT/B1 with the three functional domains indicated. Epitopes bound by the 24 mAbs used in this work are indicated. Epitope placement on each domain is arbitrary, except for epitope 5 on the H_N and epitope 7 on the LC. Epitope 5 is bound by the 1B18 family of mAbs which bind the tip of the H_N, as indicated (Geren IN, Garcia-Rodriguez C, Lou J, Conrad F, Fan F, et al: Human monoclonal antibodies to botulinum neurotoxin types A and B from immune yeast displayed antibody libraries, submitted). Epitope 7 is bound by 1B10.1, which has been mapped to the indicated location on the LC (data unpublished).