Interaction between JMJD2A double Tudor domain and R19 in H4K20me3 peptide. The backbone of JMJD2A double Tudor domain (pdb entry 2QQS) is shown in orange. Amino acid side chains of the Tudor domains either interacting with H4K20me3 or H4R19 are shown in red. The H4-peptide backbone is shown in a medium blue with the side chains of K20me3 and R19 highlighted in a dark blue. The side chains of F932, D934, Y973 and W967 form an aromatic cage around the trimethylated lysine 20, while the side chains of F937 and D939 interact with unmodified R19. The distances of the side chains atoms of D939 and F937 to R19 are indicated.
Bock et al. BMC Biochemistry 2011 12:48 doi:10.1186/1471-2091-12-48