What’s next for clinical trials?

BMC is celebrating Clinical Trials Day 2018 by curating a selection of recent article highlights on clinical trials, coinciding with the Society for Clinical Trials 2018 Conference, of which our journal Trials is a proud sponsor.

Test yourself with our Clinical Trials Day Quiz!

In celebration of Clinical Trials Day we’re challenging you with a quiz on recent initiatives to improve trial conduct and reporting, and ultimately reduce waste in research.

Take our quiz

What’s next for trial registration?

The ISRCTN Registry team provide an insight into the dynamic nature of trial registration, and the role it plays in the ever-changing landscape of clinical trials in their new blog.

Featured articles

Adaptive designs

Adaptive designs in clinical trials: why use them, and how to run and report them
BMC Medicine

Bayesian dose selection design for a binary outcome using restricted response adaptive randomization Trials

(Big) Data and trials

Data sharing in clinical trials – practical guidance on anonymising trial datasets Trials

Resource implications of preparing individual participant data from a clinical trial to share with external researchers Trials

Routinely collected data for randomized trials: promises, barriers, and implications Trials

Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access Trials

Cluster and stepped wedge designs

Analysis of cluster randomised stepped wedge trials with repeated cross-sectional samples Trials

Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features Trials

Understanding the cluster randomised crossover design: a graphical illustraton of the components of variation and a sample size tutorial Trials

Improving trial design and conduct

Barriers to the conduct of randomised clinical trials within all disease areas Trials

Patient and public involvement in reducing health and care research waste
Research Involvement and Engagement

Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)? Trials

The COMET Handbook: version 1.0 Trials

Pragmatic trials

Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? BMC Medicine

Recruitment and retention

Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework Trials

Identifying research priorities for effective retention strategies in clinical trials Trials

Identifying trial recruitment uncertainties using a James Lind Alliance Priority Setting Partnership – the PRioRiTy (Prioritising Recruitment in Randomised Trials) study Trials

Patient-centered recruitment and retention for a randomized controlled study Trials

No matter what your design, pilot studies are crucial for conducting efficient and cost-effective trials

Pilot and Feasibility Studies is uniquely positioned to improve the design, conduct and reporting of these studies, along with the studies that they will directly influence. The journal considers general methodology, commentaries, study protocols and research papers - regardless of outcome or significance of findings.

Featured blog

A timeline for conducting your clinical trial

Recap on our timeline for conducting your clinical trial, where BMC invited some of the greats in the field to comment on why each stage is important to a trial, what should be considered, and why it should be considered at that point in the trial timeline.
Read more

ISRCTN Trial Registry

ISRCTN trial registry

The ISRCTN registry is a primary clinical trial registry recognized by WHO and ICMJE that accepts all clinical research studies (whether proposed, ongoing or completed), providing content validation and curation and the unique identification number necessary for publication.

Why register with us?

Register any study design at any time – we accept prospective and retrospective registration
Benefit from editorial help – expert editors will advise you and update your study at key milestones
Bring your research to a wider audience – records include plain English summaries and appear on the WHO and UKCTG portals
Share all aspects of your study – records can include data sharing plans and basic results

Register your trial today