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Evolution and cancer: A mathematical biology approach II

Hindersin et al. 2016Edited by Professor Marek Kimmel

In 2010 Biology Direct published a collection of articles highlighting the various ways evolutionary mechanisms relate to cancer, and how these mechanisms can be modelled mathematically. This new series is similarly concerned with the ways evolution is intertwined with cancer, and highlights progress made during the intervening years since 2010.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor declares no competing interests.

  1. Evolutionary game theory (EGT) has been widely used to simulate tumour processes. In almost all studies on EGT models analysis is limited to two or three phenotypes. Our model contains four main phenotypes. Mo...

    Authors: Andrzej Świerniak and Michał Krześlak
    Citation: Biology Direct 2016 11:53
  2. Leukemias are malignant proliferative disorders of the blood forming system. Sequencing studies demonstrate that the leukemic cell population consists of multiple clones. The genetic relationship between the d...

    Authors: Thomas Stiehl, Christoph Lutz and Anna Marciniak-Czochra
    Citation: Biology Direct 2016 11:51
  3. A thorough understanding of the ecological and evolutionary mechanisms that drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer research community. In this respect, ...

    Authors: Tommaso Lorenzi, Rebecca H. Chisholm and Jean Clairambault
    Citation: Biology Direct 2016 11:43
  4. Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal cr...

    Authors: Leili Shahriyari, Natalia L. Komarova and Alexandra Jilkine
    Citation: Biology Direct 2016 11:42