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Evolution and cancer: A mathematical biology approach II

Hindersin et al. 2016Edited by Professor Marek Kimmel

In 2010 Biology Direct published a collection of articles highlighting the various ways evolutionary mechanisms relate to cancer, and how these mechanisms can be modelled mathematically. This new series is similarly concerned with the ways evolution is intertwined with cancer, and highlights progress made during the intervening years since 2010.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor declares no competing interests.

  1. Research

    Cancer heterogeneity and multilayer spatial evolutionary games

    Evolutionary game theory (EGT) has been widely used to simulate tumour processes. In almost all studies on EGT models analysis is limited to two or three phenotypes. Our model contains four main phenotypes. Mo...

    Andrzej Świerniak and Michał Krześlak

    Biology Direct 2016 11:53

    Published on: 13 October 2016

  2. Research

    Emergence of heterogeneity in acute leukemias

    Leukemias are malignant proliferative disorders of the blood forming system. Sequencing studies demonstrate that the leukemic cell population consists of multiple clones. The genetic relationship between the d...

    Thomas Stiehl, Christoph Lutz and Anna Marciniak-Czochra

    Biology Direct 2016 11:51

    Published on: 12 October 2016

  3. Review

    Optimal treatment and stochastic modeling of heterogeneous tumors

    In this work we review past articles that have mathematically studied cancer heterogeneity and the impact of this heterogeneity on the structure of optimal therapy. We look at past works on modeling how hetero...

    Hamidreza Badri and Kevin Leder

    Biology Direct 2016 11:40

    Published on: 23 August 2016